Miami, FL, USA, 27 March 2016 | AAP/AP

Nick Kyrgios has advanced to the third round at the Miami Open with a routine win on Saturday at the Masters event.

Kyrgios made short work of Cypriot Marcos Baghdatis, defeating him 6-2 6-1 in just under an hour and firing down 14 aces in the impressive victory.

Kyrgios was seeded to face big-serving American veteran John Isner but the world No.13 became yet another seeded casualty – on a day in which Stan Wawrinka and Rafael Nadal exited – in Miami, going down to countryman and world No.132 Tim Smyczek 6-2 2-6 7-6(5).

Kyrgios’ quarter of the draw is now wide open and if he beats Smyczek he will face a player ranked below him for a spot in the quarters.

While Kyrgios made it through there was no such luck for Australian journeyman John Millman.

Millman fell 7-5 6-4 in his second round match to Uruguayan 23rd seed Pablo Cuevas.

One break of serve in each set enough to send Millman, who couldn’t force a break point on Cuevas’ serve packing.