John Millman beats Mikhail Kukushkin to reach the fourth round of a Grand Slam for the first time at the US Open.

Ash Barty reaches the fourth round in singles for the first time at a Grand Slam with victory over Karolina Muchova at the US Open.

Australia will face competition from 18 other Oceania nations at the event in Samoa next week.

Australian 18th seed Ash Barty lines up against Czech qualifier Karolina Muchova at the US Open on Friday, while Matt Ebden and Ajla Tomljanovic fly the Aussie flag in doubles.

John Millman upsets 14th seed Fabio Fognini while Nick Kyrgios meets Roger Federer in a highly-anticipated third-round clash at the US Open after beating Pierre-Hugues Herbert.

Nick Kyrgios, Alex De Minaur, Matt Ebden, John Millman and Ajla Tomljanovic will shoot for the third round at the US Open on a bumper day's play on Thursday.

For the second straight year, Ash Barty has advanced to the last 32 at the US Open, where she could face two-time Grand Slam champion Garbine Muguruza.

Jason Kubler suffers injury heartbreak at the US Open while Daria Gavrilova proves no match for a resurgent Victoria Azarenka.

Daria Gavrilova faces Victoria Azarenka, Ash Barty takes on Lucie Safarova and Jason Kubler tackles Taylor Fritz on day three of the US Open.

Ajla Tomljanovic gets the better of fellow Queenslander Lizette Cabrera to advance to the second round of the US Open.